Combined immunostaining with galectin-3, fibronectin-1, CITED-1, Hector Battifora mesothelial-1, cytokeratin-19, peroxisome proliferator-activated receptor-g, and sodium/iodide symporter antibodies for the differential diagnosis of non-medullary thyroid carcinoma
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چکیده
Combined immunostaining with galectin-3, fibronectin-1, CITED-1, Hector Battifora mesothelial-1, cytokeratin-19, peroxisome proliferator-activated receptor-g, and sodium/iodide symporter antibodies for the differential diagnosis of non-medullary thyroid carcinoma Ying Y Liu, Hans Morreau, Job Kievit, Johannes A Romijn, Nancy Carrasco and Johannes W Smit Department of Endocrinology, C4-R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands, Departments of Pathology, Medical Decision Making and Surgery, Leiden University Medical Center, NL-2300RC Leiden, The Netherlands and Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, NY-10461 USA
منابع مشابه
Combination of galectin-3, CK19 and HBME-1 immunostaining improves the diagnosis of thyroid cancer
Currently, fine-needle aspiration is the most frequently used pre-operative technique for diagnosis of malignant thyroid tumors, however, pathologists are unable to reach efficient and accurate differential diagnoses between benign and malignant thyroid nodules. To aid in resolving this issue, immunohistochemistry for galectins (gal)-1, -3, -7, -8, cytokeratin 19 (CK19), Hector Battifora Mesoth...
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BACKGROUND We subjected chemokine (C-X-C motif) ligand 12 (CXCL12) to immunohistochemistry to determine its utility as a novel diagnostic marker for papillary thyroid carcinoma (PTC) in comparison to cytokeratin 19 (CK19), Hector Battifora mesothelial epitope-1 (HBME-1), and galectin-3. METHODS We analyzed the expressions of CXCL12, CK19, HBME-1, and galectin-3 using immunohistochemical stain...
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OBJECTIVES Human trophoblast cell-surface marker (TROP-2) has been reported to be overexpressed in various human carcinomas (CAs) and suggested to be a prognostic marker for some CAs. The diagnostic utility of TROP-2 in CAs has not been explored. METHODS Immunohistochemical evaluation of TROP-2 expression on tissue microarray sections of 136 thyroid neoplasms, surgical specimens of 61 atypica...
متن کاملUsefulness of HBME-1, cytokeratin 19 and galectin-3 immunostaining in the diagnosis of thyroid malignancy.
AIMS To investigate the usefulness of immunohistochemical expression and immunolocalization of a panel of thyroid malignancy markers including HBME-1, cytokeratin (CK) 19 and galectin-3. METHODS AND RESULTS We evaluated 170 thyroid lesions including 148 neoplastic lesions [84 papillary carcinomas (PC), 38 follicular carcinomas (FC), 18 follicular adenomas, one hyalinizing trabecular tumour, f...
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BACKGROUND Follicular thyroid carcinoma (FTC) is the second most common thyroid malignancy and its differential diagnosis includes follicular adenoma (FA) and adenomatous goiter (AG). Several ancillary markers have been suggested to aid in the diagnosis of FTC, but the successful use of these methods still needs to be validated. METHODS In the present study, we verified the immunoexpression o...
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